PROFESSIONAL AESTHETIC EQUIPMENT

Clinical Research & Evidence Library

For Canadian Clinics & Medspas

Every device in DermaSpark’s portfolio is chosen through the same process: we review the clinical evidence before we ever bring a device to market. This library exists so that you can do the same.

Here you’ll find links to peer-reviewed studies, clinical trials, and published research for each piece of equipment we distribute. Whether you’re building a business case, satisfying a compliance requirement, or doing your due diligence, the science is organized by device.

All equipment sold by DermaSpark is licensed by Health Canada and CSA-approved. The research below reflects the clinical standards we hold ourselves and our partners to.

Health Canada Licensed Health Canada Licensed
CSA Approved CSA Approved
Peer-Reviewed / Published Research Peer-Reviewed / Published Research

Alpha Laser

A Paradigm Shift Towards Intelligent, Biologically Adaptive Diode Laser Hair Removal

Dr. Nadav Pam M.D, Thoma Gruot

Diode Laser Hair Removal

This large-scale retrospective study spans more than 4 years, involving 338 sites across France, 45,467 patients, and approximately 200,000 laser hair removal sessions with the Alpha system. This study shows that under real-world operational settings, Alpha's adaptive biology approach provides personalized, safer, and more effective hair removal treatments that produce long-term results with up to 33% fewer sessions per patient.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: No

Integrated Acne Management Using the Alpha System 3D IPL 430nm Applicator in Combination with Professional Topical Dermocosmetics

Alpha Clinical Research (MR19131-A) – 2026

Dr. Nadav Pam M.D, Limor Biton

IPL Acne

This case series demonstrates that the combined use of the Alpha System 430 nm 3D IPL with an adjunctive cosmeceutical regimen resulted in rapid and consistent clinical improvement in inflammatory acne vulgaris under real-world conditions, and without significant adverse effects for patients.

Device: Alpha Laser
Technology: IPL
Indication: Acne
Health Canada: No

Case Studies Compilation — Clinical Outcomes Across Multiple Modalities

Alpha Clinical Publications – 2025

Formatk

Diode Laser IPL Acne Hair Removal Pigmentation Redness Rejuvenation Rosacea

This compiled case series presents real-world clinical outcomes across multiple Alpha System modalities, including IPL, diode laser, and combination treatments. Cases span a range of skin types and indications, illustrating protocol flexibility and the system's adaptability across diverse patient populations.

Device: Alpha Laser
Technology: Diode Laser, IPL
Indication: Acne, Hair Removal, Pigmentation, Redness, Rejuvenation, Rosacea
Health Canada: Yes

3D IPL Photo Rejuvenation and Pigmentation Protocol

Alpha Clinical Publication – 2023

Dr. Nadav Pam M.D, Veronica Yehoshua

IPL Pigmentation Rejuvenation

This protocol document evaluates the clinical application of 3D IPL technology for photo rejuvenation and the reduction of pigmentation irregularities. Results demonstrate measurable improvement in skin tone uniformity and the reduction of solar lentigines after a standardized multi-session treatment course.

Device: Alpha Laser
Technology: IPL
Indication: Pigmentation, Rejuvenation
Health Canada: Yes

Canadian hair removal case study – preliminary result with the Alpha System using LLD laser Diode, 3rd generation POWER MOTION™

Alpha Internal Clinical Trial (Dr. Nadav) – 2023

Dr. Nadav Pam M.D, Shannon Roche, Amanda Killan, Lacey Allen

Diode Laser Hair Removal

This internal clinical trial aims to assess the preliminary safety and clinical efficacy of hair removal using the third-generation POWER-MOTION™ LLD 808nm non-invasive diode laser applicator. This case study highlights the Alpha system with the third-generation POWER-MOTION™ LLD Diode laser 808nm applicator as a safe and effective hair removal solution for patients with Fitzpatrick skin types I to III.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: Yes

Case Study: Versatility of the Alpha System with three 3D IPL applicators – 430 nm / 530 nm / 590 nm

Alpha Internal Clinical Trial (Dr. Nadav) – 2023

Dr. Nadav Pam, Clinical Director at FormaTK | Nina Verhoek, Dermal Clinician, Co-Owner Skincosmediq Clinic | Amal Raoudi, Dermal Clinician, Co-Owner Skincosmediq Clinic

IPL Hair Removal Pigmentation Stretch Marks

This 2024–2026 case series evaluates the Formatk Alpha System using three wavelength-specific 3D IPL applicators (430 nm, $530 nm, and 590 nm). Treating 22 patients, the versatile platform achieved an 85.9% mean clinical improvement across diverse dermatologic indications—including active acne, rosacea, and photoaging—with excellent tolerability and no serious adverse events.

Device: Alpha Laser
Technology: IPL
Indication: Hair Removal, Pigmentation, Stretch Marks
Health Canada: Yes

Lichtkraft Strahlend Schön: German Clinical Experience with SparkPro 3D IPL 530 nm for Tight & Bright Skin Outcomes

Alpha Clinical Case Study – 2023

Dr. Nadav Pam M.D, Ramona Weber

IPL Pigmentation Redness Rejuvenation Rosacea

Documenting clinical experience from a German aesthetic practice, this case study evaluates the SparkPro 3D IPL at 530 nm for combined skin tightening and brightening outcomes. Patients showed improvement in skin luminosity, pore appearance, and superficial pigmentation after a defined multi-session protocol.

Device: Alpha Laser
Technology: IPL
Indication: Pigmentation, Redness, Rejuvenation, Rosacea
Health Canada: Yes

Male Hair Removal with the Alpha System Featuring 3rd Generation POWER-MOTION™ LLD Diode Laser

Alpha Clinical Case Study (MR19218-1) – 2023

Dr. Nadav Pam M.D, Veronica Yehoshua

Diode Laser Hair Removal

This case study documents the use of the third-generation POWER-MOTION™ diode laser in male patients seeking body hair removal. The POWER-MOTION™ technique enabled faster treatment coverage and higher pulse repetition rates, producing effective clearance with patient-reported comfort levels comparable to female treatment cohorts.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: Yes

One-Year Follow-Up Hair Removal Study with the Alpha System Using ALD Laser Diode: Split-Body Comparison — 3rd Generation POWER-MOTION™ vs. 1st Generation Stamping Mode

Alpha Clinical Research (MR19209) – 2023

Dr. Nadav Pam M.D, Veronica Yehoshua

Diode Laser Hair Removal

This split-body study followed patients for one year post-treatment, comparing 3rd generation POWER-MOTION™ outcomes against 1st generation stamping on contralateral body sites. Long-term hair clearance was superior in the POWER-MOTION™ arm, with faster treatment delivery and comparable safety across both techniques.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: Yes

The Synergistic and Complementary Action of Polychromatic IPL 590–1100 nm in Combination with the 808 nm Diode Laser in Managing Miniaturisation of Facial Hair

Alpha Clinical Research – 2023

Dr. Nadav Pam M.D, Veronica Yehoshua

Diode Laser IPL Hair Removal

This study examined a combined treatment protocol using broadband IPL (590–1100 nm) alongside the 808 nm diode laser for patients experiencing facial hair miniaturisation — a condition where hairs become finer and harder to target effectively. The combination approach proved more effective than either modality alone in halting miniaturisation and reducing hair density.

Device: Alpha Laser
Technology: Diode Laser, IPL
Indication: Hair Removal
Health Canada: Yes

3D Pulse Technology and the Importance of Temperature Control

Alpha Technical White Paper – 2022

Sharona Levi-Friedman CRA, E. Krieger M.D

IPL

This white paper examines the role of precise thermal management in third-generation 3D IPL pulse delivery. Findings indicate that real-time temperature control significantly reduces the risk of epidermal injury while maintaining the fluence levels required for effective chromophore targeting.

Device: Alpha Laser
Technology: IPL
Health Canada: Yes

Alpha System 3D IPL S-430 Treatment for Acne Vulgaris

Alpha Clinical Research (MR19203-1) – 2022

Dr. Nadav Pam M.D, Veronica Yehoshua

IPL Acne

This study assessed the clinical outcomes of repeated IPL S-430 sessions for the treatment of mild-to-moderate acne vulgaris. Inflammatory lesion counts decreased by a statistically significant margin across the treatment cohort, and patients reported improvements in skin texture and overall complexion quality at the 3-month follow-up.

Device: Alpha Laser
Technology: IPL
Indication: Acne
Health Canada: Yes

Alpha System IPL S-530 Treatment for Rosacea and Facial Telangiectasia

Alpha Clinical Case Series (MR19202-1) – 2022

Dr. Nadav Pam M.D, Veronica Yehoshua

IPL Redness Rosacea

This case series documents patient outcomes following IPL S-530 treatment for diffuse facial redness and visible telangiectasia associated with rosacea. Practitioners recorded consistent vascular clearance and reduction in erythema across patients with moderate presentations, without significant adverse events.

Device: Alpha Laser
Technology: IPL
Indication: Redness, Rosacea
Health Canada: Yes

Alpha System Single-Site Hair Removal Comparison Study: POWER-MOTION™ vs. Stamping Technique

Alpha Clinical Research (MR-19204) – 2022

Dr. Nadav Pam M.D, Veronica Yehoshua

Diode Laser Hair Removal

This head-to-head comparison study evaluated the POWER-MOTION™ gliding technique against the traditional stamping method for hair removal at a single clinical site. POWER-MOTION™ demonstrated equivalent or superior hair reduction in significantly shorter treatment times, while patient discomfort scores favoured the dynamic delivery method.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: Yes

Efficacy and Safety of Intense Pulsed Light Therapy for Unwanted Facial Hair: A Retrospective Analysis in Skin of Color

Peer-Reviewed Aesthetic Publication (Ajay Deshpande) – 2022

Ajay Deshpande

IPL Hair Removal

This retrospective analysis examined the use of IPL for facial hair reduction specifically in patients with Fitzpatrick skin types IV–VI. The study reported effective hair reduction with careful parameter selection and identified a protocol framework that minimizes hyperpigmentation risk in darker skin tones.

Device: Alpha Laser
Technology: IPL
Indication: Hair Removal
Health Canada: Yes

FineMotion™: A Paradigm Shift in Pulse-Modulated LLD/ALD 808 nm Diode Laser Treatment of Fine and Vellus Hair in Female Patients

Alpha Clinical Case Study (MR19130-1) – 2022

Dr. Nadav Pam M.D, Veronica Yehoshua, Thomas Gruot

Diode Laser Hair Removal

This case study evaluates the FineMotion™ technique for treating fine and vellus facial hair in female patients using an 808 nm diode laser. Results showed effective reduction of difficult-to-treat hair types with minimal discomfort, representing a meaningful advancement for patients previously considered poor candidates for laser hair removal.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: Yes

Innovating Skin Care: The Alpha 3D IPL S-430 for Early Acne Intervention and Scar Prevention

Alpha Clinical Case Study (MR19126-A) – 2022

Dr. Nadav Pam MD, Veronica Yehoshua

IPL Acne

This case study evaluates early-stage acne treatment with the IPL S-430 as a scar prevention strategy. By targeting Propionibacterium acnes and reducing sebaceous activity at earlier stages of breakout, the protocol demonstrated a reduction in inflammatory lesion progression and secondary scarring outcomes.

Device: Alpha Laser
Technology: IPL
Indication: Acne
Health Canada: Yes

IPL S-430 Acne Results in Asian Skin

Alpha Clinical Case Series – 2022

Dr. Nadav Pam M.D, Dr. Nguyễn Hoàng Nam M.D, Dr. Lê Thị Vân Anh M.D

IPL Acne

This case series documents the use of the IPL S-430 for acne treatment in Asian patients with Fitzpatrick skin types III–IV. Results indicated effective suppression of inflammatory acne with adapted fluence parameters, demonstrating that the S-430 can be applied safely in populations with higher melanin density when protocols are appropriately adjusted.

Device: Alpha Laser
Technology: IPL
Indication: Acne
Health Canada: Yes

Laser-Based Precision Facial Hair Removal in Women Using the Alpha SparkPro 808 nm Diode Laser in Single-Stamping Mode

Alpha Clinical Case Study (MR19128-A) – 2022

Dr. Nadav Pam M.D, Beyza Isik

Diode Laser Hair Removal

This case study evaluates the single-stamping mode of the Alpha SparkPro 808 nm diode laser for precise removal of facial hair in female patients. The stamping technique allowed targeted treatment of individual follicles in sensitive facial regions, producing effective clearance with minimal erythema and high patient tolerance.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: Yes

Unwanted Bikini Area Hair Removal in German Female Patients Treated with the ALPHA SparkPro System Using an 808 nm Diode Laser

Alpha Clinical Case Study (MR19129-A) – 2022

Dr. Nadav Pam M.D, Agnessa Schindler,

Diode Laser Hair Removal

This case study reports outcomes for female patients undergoing bikini area hair removal using the ALPHA SparkPro 808 nm diode laser in a German clinical setting. Consistent hair reduction was achieved across sessions, with low rates of adverse events and strong patient satisfaction in a sensitive treatment zone.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: Yes

Alleviating Skin Pigmentation Using 3D IPL: A Retrospective Study

Alpha Clinical Research – 2021

Nina Talib B.Sc

IPL Pigmentation Rejuvenation

This retrospective analysis reviewed outcomes in patients treated for various pigmentation concerns using the 3D IPL platform. The study found a clinically significant reduction in melanin-based lesions across multiple Fitzpatrick skin types, with a favorable safety profile and high patient satisfaction scores.

Device: Alpha Laser
Technology: IPL
Indication: Pigmentation, Rejuvenation
Health Canada: Yes

Beyond Redness: Practical Rosacea Management with 590 nm 3D IPL, Targeted Topical Therapy, and Demodex-Guided Assessment

Alpha Clinical Case Study (MR17205-A) – 2021

Dr. Nadav Pam M.D, Alicja Zaremba

IPL Redness Rosacea

This case study presents a multimodal protocol combining 590 nm 3D IPL with topical agents and Demodex mite assessment in rosacea management. The integrated approach produced superior outcomes to IPL monotherapy, including reduced inflammatory papules and prolonged remission periods.

Device: Alpha Laser
Technology: IPL
Indication: Redness, Rosacea
Health Canada: Yes

Magma Clinical Study — Diode Laser Hair Removal

Alpha / Magma Clinical Publication – 2016

Sharona Levi – Friedman CRA, Eran Krieger M.D

Diode Laser Hair Removal

One of the foundational diode laser hair removal studies supporting the Alpha platform's lineage, this clinical study evaluated hair removal efficacy using Magma diode laser technology across a mixed patient cohort. Hair count reduction was significant at the 6-month follow-up, establishing baseline benchmarks that subsequent generations of the technology have continued to improve upon.

Device: Alpha Laser
Technology: Diode Laser
Indication: Hair Removal
Health Canada: Yes

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    Dermalux

    Combined LED Wavelengths for Facial Hypervascularization

    Photobiomodulation, Photomedicine, and Laser Surgery (P. Naranjo) – 2023

    Pablo Naranjo Garcia, PhD, M.D, and Rodolfo Lopez Andrino, M.D

    LED Phototherapy Redness Rosacea

    This peer-reviewed study assessed the use of multi-wavelength LED therapy in reducing facial hypervascularization and diffuse redness. The combined light protocol produced measurable reduction in vessel visibility and patient-reported flushing after a defined session series, with no adverse thermal effects on surrounding tissue.

    Device: Dermalux
    Technology: LED Phototherapy
    Indication: Redness, Rosacea
    Health Canada: Yes

    Tri-Wave MD: Role of Photo-Biomodulation Therapy in Facial Rejuvenation and Facial Plastic Surgery

    Photobiomodulation Clinical Paper — Dermalux – 2022

    Jose A. De Cordova, MD, FRCS

    LED Phototherapy Acne Photo-Damage Pigmentation Post-Treatment Inflammation Rejuvenation Scars

    This paper presents the clinical evidence supporting the Tri-Wave MD protocol, which delivers simultaneous red, blue, and near-infrared LED wavelengths. Clinical outcomes documented include accelerated wound healing, reduction in post-procedure erythema, and significant improvement in skin texture across cosmetic and dermatological patient cohorts.

    Device: Dermalux
    Technology: LED Phototherapy
    Indication: Acne, Photo-Damage, Pigmentation, Post-Treatment Inflammation, Rejuvenation, Scars
    Health Canada: Yes

    LED Photobiomodulation Therapy in the Management of Psoriasis

    Clinical LED Research Publication – 2021

    Derek Ho BS, Eugene Koo MS, Andrew Mamalis M.D MS, Jared Jagdeo M.D MS

    LED Phototherapy Psoriasis

    This clinical paper reviewed the application of photobiomodulation using LED light therapy in psoriasis management. Patients with plaque psoriasis showed reductions in lesion severity scores after regular LED sessions, offering a non-pharmacological adjunct that is well tolerated and free of the side effects associated with systemic treatments.

    Device: Dermalux
    Technology: LED Phototherapy
    Indication: Psoriasis
    Health Canada: Yes

    LED Technology in Aesthetic Medicine: A Technical Overview

    Aesthetic Dermatology Clinical Review – 2020

    Dale Needham

    LED Phototherapy

    This overview article surveys the evidence base for LED light therapy across a range of aesthetic dermatology applications, including wound healing, anti-ageing, acne, and skin rejuvenation. The paper reinforces the clinical rationale for multi-wavelength LED platforms and documents the mechanism by which targeted photons stimulate mitochondrial activity in skin cells.

    Device: Dermalux
    Technology: LED Phototherapy
    Health Canada: Yes

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      Dermaroller

      Hair Growth Clinical Study Using Dermaroller Microneedling

      Dermaroller Clinical Research – 2024

      Dermaroller GmbH

      Microneedling Hair Loss

      This clinical study evaluated the use of Dermaroller microneedling as a standalone and combination treatment for hair loss and scalp stimulation. Results demonstrated measurable improvement in hair density and follicle activation at the study endpoint, supporting microneedling as a viable adjunct in non-surgical hair restoration protocols.

      Device: Dermaroller
      Technology: Microneedling
      Indication: Hair Loss
      Health Canada: Yes

      Medical Studies Summary Booklet — Dermaroller Twist Microneedling

      Dermaroller Clinical Evidence Compendium – 2023

      Dermaroller GmbH

      Microneedling Laxity Rejuvenation Scars Stretch Marks Wrinkle Reduction

      This evidence compendium summarizes the body of peer-reviewed research supporting microneedling as a collagen induction therapy. Key findings across multiple studies confirm that controlled micro-injuries from the Twist Microneedling system stimulate neocollagenesis, improving skin laxity, scarring, and texture with minimal downtime.

      Device: Dermaroller
      Technology: Microneedling
      Indication: Laxity, Rejuvenation, Scars, Stretch Marks, Wrinkle Reduction
      Health Canada: Yes

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        Divine Pro

        Combination of OxyGeneo, TriPollar RF, and RF Microneedling for skin regeneration in Indonesian Females

        Journal of Dermatology Research – 2025

        Glenn Sugandi, Yuri Vinshtok, M.D

        Oxygeneo Radiofrequency RF Microneedling Rejuvenation Scars Wrinkle Reduction

        This clinical study examines the safety and efficacy of a novel protocol combining Divine Pro RF Microneedling with non-invasive TriPollar RF therapy and Oxygeneo therapy for the rejuvenation of Asian female skin. Results demonstrate significant smoothing and tightening, with a more defined jawline and a clearer complexion, one month after protocol completion. The treatment was proven safe for Asian skin with greatly reduced downtime.

        Device: Divine Pro
        Technology: Oxygeneo, Radiofrequency, RF Microneedling
        Indication: Rejuvenation, Scars, Wrinkle Reduction
        Health Canada: No

        Microneedling With RF- Assisted Skin Penetration Improves the Hard- to- Treat Periorbital Wrinkles

        Dorina Cheles, M.D, Yuri Vinshtok, M.D, Amikam Gershonowitz, D.V.M

        RF Microneedling Rejuvenation Wrinkle Reduction

        This clinical study examines the safety and efficacy of VoluDerm RF Microneedling for the correction of periorbital wrinkles.The results demonstrated a statistically significant reduction in periorbital wrinkle severity, with an average 49% decrease of LFW score and improvements noted across all skin types. The treatment was well tolerated without anesthetics, with minimal downtime and few adverse events, which were transient and resolved without intervention.

        Device: Divine Pro
        Technology: RF Microneedling
        Indication: Rejuvenation, Wrinkle Reduction
        Health Canada: No

        Therapeutic Combination of VoluDerm Radiofrequency Microneedling and Glycolic Acid Peel in Scaled-Up Concentrations

        Alex Levenberg, M.D, Yuri Vinshtok, M.D, and Amikam Gershonowitz, D.V.M

        Chemical Peels RF Microneedling Pigmentation Pore Reduction Redness Rejuvenation Wrinkle Reduction

        This clinical study examines the safety and efficacy of a novel rejuvenation protocol combining Divine Pro RF Microneedling with Glycolic Acid chemical peel. Clinical photography taken 6 months after the last treatment demonstrated improvement in elasticity, wrinkling, roughness, pigmentation, erythema, and pore size across the entire treated group. The treatments were well tolerated without preprocedural anesthesia. No serious or systemic events that would require therapy were identified.

        Device: Divine Pro
        Technology: Chemical Peels, RF Microneedling
        Indication: Pigmentation, Pore Reduction, Redness, Rejuvenation, Wrinkle Reduction
        Health Canada: Yes

        Divine Pro – Fractional RF Technologies for Skin Rejuvenation

        Divine Pro Technical White Paper – 2022

        Alex Levenberg, M.D., Amikam Gershonowitz, D.V.M, Gali Elkin – Basudo, BSc

        Radiofrequency RF Microneedling Lifting Rejuvenation Scars Tightening Wrinkle Reduction

        This white paper details the scientific basis of the Divine Pro platform's TriFractional RF microneedling system. By delivering radiofrequency energy at precise fractional depths via insulated microneedles, the device triggers controlled thermal remodelling of collagen and elastin while protecting the epidermis, producing measurable lifting and tightening outcomes with lower downtime than ablative alternatives.

        Device: Divine Pro
        Technology: Radiofrequency, RF Microneedling
        Indication: Lifting, Rejuvenation, Scars, Tightening, Wrinkle Reduction
        Health Canada: Yes

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          By submitting this inquiry form you confirm that your information will be added to our mailing list and that you have read the DermaSpark Products Privacy Policy. You can unsubscribe at any time.

          Geneo X

          Hydration Effect of Geneo X Actions on Human Skin

          QACS Laboratories Independent Testing – 2026

          Yuri Vinshtok, MD, Amikam Gershowitz, DVM

          Oxygeneo Hydration Rejuvenation

          This independent laboratory study evaluated the moisturizing properties of different OxyGeneo treatments, with and without Tripollar RF. Results demonstrate significantly higher moisture levels after 6 treatments, with improved elasticity and reduced TEWL in all patients and all Oxypod treatments

          Device: Geneo X
          Technology: Oxygeneo
          Indication: Hydration, Rejuvenation
          Health Canada: Yes

          Combination of OxyGeneo, TriPollar RF, and RF Microneedling for skin regeneration in Indonesian Females

          Journal of Dermatology Research – 2025

          Glenn Sugandi, Yuri Vinshtok, M.D

          Oxygeneo Radiofrequency RF Microneedling Rejuvenation Wrinkle Reduction

          This clinical study examines the safety and efficacy of a novel protocol combining OxyGeneo therapy with non-invasive Tripollar RF therapy and Divine Pro RF Microneedling for the rejuvenation of Asian female skin. Results demonstrate significant smoothing and tightening, with a more defined jawline and a clearer complexion, one month after protocol completion. The treatment was proven safe for Asian skin with greatly reduced downtime.

          Device: Geneo X
          Technology: Oxygeneo, Radiofrequency, RF Microneedling
          Indication: Rejuvenation, Wrinkle Reduction
          Health Canada: Yes

          OxyGeneo Treatment for Bacne (Back Acne): Clinical Test Results

          OxyGeneo Clinical Testing – 2022

          Pollogen Ltd

          Oxygeneo Acne

          These clinical test results document the application of OxyGeneo technology to truncal acne (bacne) across a patient test group. Outcomes included reduction in active inflammatory lesions and improvement in post-acne discoloration on the back, extending the device's proven facial indications to a commonly underserved body treatment area.

          Device: Geneo X
          Technology: Oxygeneo
          Indication: Acne
          Health Canada: Yes

          Geneo OxyGeneo QACS Laboratories Efficacy Study

          QACS Laboratories Independent Testing – 2020

          Pollogen Ltd

          Oxygeneo Pigmentation Rejuvenation Wrinkle Reduction

          This independent laboratory study evaluated the biological effect of the OxyGeneo Super Facial platform on skin oxygenation, hydration, and the delivery of active ingredients. Results validated the device's core Bohr Effect mechanism — whereby the skin responds to CO₂ application by increasing oxygen-rich blood flow to the surface — producing measurable increases in skin luminosity and ingredient absorption.

          Device: Geneo X
          Technology: Oxygeneo
          Indication: Pigmentation, Rejuvenation, Wrinkle Reduction
          Health Canada: Yes

          Geneo OxyGeneo QACS Laboratories Efficacy Study

          QACS Laboratories Independent Testing – 2020

          Pollogen Ltd

          Oxygeneo Pigmentation Rejuvenation Wrinkle Reduction

          This independent laboratory study evaluated the biological effect of the OxyGeneo Super Facial platform on skin oxygenation, hydration, and the delivery of active ingredients. Results validated the device's core Bohr Effect mechanism — whereby the skin responds to CO₂ application by increasing oxygen-rich blood flow to the surface — producing measurable increases in skin luminosity and ingredient absorption.

          Device: Geneo X
          Technology: Oxygeneo
          Indication: Pigmentation, Rejuvenation, Wrinkle Reduction
          Health Canada: Yes

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            By submitting this inquiry form you confirm that your information will be added to our mailing list and that you have read the DermaSpark Products Privacy Policy. You can unsubscribe at any time.

            Helios III

            Evaluating the Risk Factors of Post-Inflammatory Hyperpigmentation Complications with Nd:YAG Laser

            Clinical Aesthetic Dermatology Publication – 2021

            Liu, C.-H., Shieh, C.-S., Huang, T.-L., Lin, C.-H., Chao, P.-J., Huang, Y.-J., Lee, H.-F., Yeh, S.-A., Tseng, C.-D., Wu, J.-M., et al

            Q-Switched Laser Pigmentation

            This study specifically investigated which patient and protocol factors increase the risk of post-inflammatory hyperpigmentation (PIH) following Nd:YAG laser treatment. Key risk predictors were identified including skin phototype, baseline pigmentation density, and cooling protocols — providing actionable parameters for safer treatment planning across diverse populations.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation
            Health Canada: Yes

            A Comparative Study of the Efficacy of Fractional Nd:YAG Laser Therapy Alone vs. Combination Approaches

            Peer-Reviewed Journal (SCIE/SCOPUS Indexed) – 2020

            Nilforoushzadeh MA, Zolghadr S, Heidari-Kharaji M, Alavi S, Mahmoudbeyk M

            Q-Switched Laser Pigmentation Rejuvenation

            This comparative study evaluated fractional Nd:YAG laser monotherapy against combination modality protocols for the treatment of pigmentation and skin quality concerns. While fractional Nd:YAG alone produced clinically meaningful results, combination approaches delivered superior outcomes in melanin reduction and texture improvement.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation, Rejuvenation
            Health Canada: Yes

            A Comparative Study of the Efficacy of Fractional Nd:YAG Laser Therapy Alone vs. Combination Approaches

            Peer-Reviewed Journal (SCIE/SCOPUS Indexed) – 2020

            Nilforoushzadeh MA, Zolghadr S, Heidari-Kharaji M, Alavi S, Mahmoudbeyk M

            Q-Switched Laser Pigmentation Rejuvenation

            This comparative study evaluated fractional Nd:YAG laser monotherapy against combination modality protocols for the treatment of pigmentation and skin quality concerns. While fractional Nd:YAG alone produced clinically meaningful results, combination approaches delivered superior outcomes in melanin reduction and texture improvement.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation, Rejuvenation
            Health Canada: Yes

            Helios Clinical Paper Summary — Comprehensive Evidence Overview

            Helios Internal Clinical Summary – 2020

            Laseroptek

            Q-Switched Laser Pigmentation Rejuvenation

            This internal summary document collates the principal clinical evidence supporting the Helios platform across its key indications: tattoo removal, pigmentation, skin rejuvenation, and fungal conditions. It provides practitioners with a consolidated reference point for understanding the clinical breadth of the Q-switched Nd:YAG laser platform.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation, Rejuvenation
            Health Canada: Yes

            Helios Clinical Paper Summary — Comprehensive Evidence Overview

            Helios Internal Clinical Summary – 2020

            Laseroptek

            Q-Switched Laser Pigmentation Rejuvenation

            This internal summary document collates the principal clinical evidence supporting the Helios platform across its key indications: tattoo removal, pigmentation, skin rejuvenation, and fungal conditions. It provides practitioners with a consolidated reference point for understanding the clinical breadth of the Q-switched Nd:YAG laser platform.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation, Rejuvenation
            Health Canada: Yes

            Mycosis Treatment with the Helios II Laser System

            Helios Clinical White Paper – 2020

            Ricardo Hoogstra, M.D

            Q-Switched Laser Nail Fungus

            This white paper details the use of the Helios II Q-switched Nd:YAG laser system for the treatment of superficial mycosis. The laser's wavelength-specific penetration enabled effective targeting of fungal colonies in nail and surrounding tissue, providing an adjunctive non-pharmacological treatment option for this difficult-to-manage condition.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Nail Fungus
            Health Canada: Yes

            Onychomycosis Treatment Using the Helios II Laser System

            Helios Clinical White Paper – 2020

            Nicole Koven, PA-C, Steven Shapiro, M.D

            Q-Switched Laser Nail Fungus

            This paper evaluates the Helios II laser in the specific context of onychomycosis (fungal nail infection). Patients who completed the full treatment protocol showed measurable improvement in nail clarity and reduction in fungal load, with the laser offering a safe and well-tolerated alternative to oral antifungals.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Nail Fungus
            Health Canada: Yes

            Onychomycosis Treatment Using the Helios II Laser System

            Helios Clinical White Paper – 2020

            Nicole Koven, PA-C, Steven Shapiro, M.D

            Q-Switched Laser Nail Fungus

            This paper evaluates the Helios II laser in the specific context of onychomycosis (fungal nail infection). Patients who completed the full treatment protocol showed measurable improvement in nail clarity and reduction in fungal load, with the laser offering a safe and well-tolerated alternative to oral antifungals.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Nail Fungus
            Health Canada: Yes

            Laser Skin Rejuvenation with Fractional 1064 Q-Switched Nd:YAG in 252 Patients

            Peer-Reviewed Journal (SCIE/SCOPUS Indexed) – 2019

            Madhuri Agarwal, MBBS, MD, DDV, Sangeeta Velaskar, MBBS, MD, DVD

            Q-Switched Laser Pigmentation Rejuvenation

            This large-cohort study followed 252 patients treated with fractional 1064 nm Q-switched Nd:YAG laser for skin rejuvenation. Outcomes included significant improvement in overall skin tone, pore size, and superficial pigmentation, with an acceptable safety profile across Fitzpatrick types II–V.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation, Rejuvenation
            Health Canada: Yes

            Laugier-Hunziker Syndrome: Complete Clearance of Mucosal Lentigines

            Peer-Reviewed Dermatology Journal (SCIE/SCOPUS Indexed) – 2019

            Vivek Nair

            Q-Switched Laser Oral Pigmentation

            This clinical report documents complete clearance of mucosal pigmented lesions in a patient diagnosed with Laugier-Hunziker syndrome, a rare benign condition causing pigmentation of the lips and oral mucosa. Q-switched Nd:YAG laser treatment achieved full clearance with no recurrence at the reported follow-up period.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Oral Pigmentation
            Health Canada: Yes

            Effects of Picosecond Laser on Multicoloured Tattoo Removal Using Hartley Guinea Pig Model

            Peer-Reviewed Dermatology Journal (SCIE/SCOPUS Indexed) – 2018

            Choi MS, Seo HS, Kim JG, Choe SJ, Park BC, Kim MH, Hong SP

            Q-Switched Laser Tattoo Removal

            This pre-clinical study used the Hartley guinea pig model to evaluate the effectiveness of picosecond laser pulses on multicoloured tattoo ink removal. The picosecond delivery produced superior ink particle fragmentation compared to nanosecond controls, particularly for difficult-to-clear pigments such as green and blue, laying groundwork for clinical application in multi-ink tattoo removal.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Tattoo Removal
            Health Canada: Yes

            Effects of Picosecond Laser on Multicoloured Tattoo Removal Using Hartley Guinea Pig Model

            Peer-Reviewed Dermatology Journal (SCIE/SCOPUS Indexed) – 2018

            Choi MS, Seo HS, Kim JG, Choe SJ, Park BC, Kim MH, Hong SP

            Q-Switched Laser Tattoo Removal

            This pre-clinical study used the Hartley guinea pig model to evaluate the effectiveness of picosecond laser pulses on multicoloured tattoo ink removal. The picosecond delivery produced superior ink particle fragmentation compared to nanosecond controls, particularly for difficult-to-clear pigments such as green and blue, laying groundwork for clinical application in multi-ink tattoo removal.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Tattoo Removal
            Health Canada: Yes

            Combined Vitamin C Sonophoresis and Nd:YAG Laser for Facial Hyperpigmentation

            Peer-Reviewed Dermatology Journal (SCIE/SCOPUS Indexed) – 2016

            Chen YT, Chang CC, Hsu CR, Shen JH, Shih CJ, Lin BS.

            Q-Switched Laser Pigmentation Rejuvenation

            This study tested the combination of topical vitamin C delivered via sonophoresis alongside Q-switched Nd:YAG laser sessions for facial hyperpigmentation. The combined approach produced greater reduction in melanin index scores than either treatment alone, suggesting a synergistic effect between laser-based disruption and antioxidant-assisted pigment clearance.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation, Rejuvenation
            Health Canada: Yes

            Combined Vitamin C Sonophoresis and Nd:YAG Laser for Facial Hyperpigmentation

            Peer-Reviewed Dermatology Journal (SCIE/SCOPUS Indexed) – 2016

            Chen YT, Chang CC, Hsu CR, Shen JH, Shih CJ, Lin BS.

            Q-Switched Laser Pigmentation Rejuvenation

            This study tested the combination of topical vitamin C delivered via sonophoresis alongside Q-switched Nd:YAG laser sessions for facial hyperpigmentation. The combined approach produced greater reduction in melanin index scores than either treatment alone, suggesting a synergistic effect between laser-based disruption and antioxidant-assisted pigment clearance.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation, Rejuvenation
            Health Canada: Yes

            Using a Low-Fluence Q-Switched 532/1064 nm Nd:YAG Laser for Facial Skin Depigmentation

            Peer-Reviewed Dermatology Journal (SCIE/SCOPUS Indexed) – 2016

            Shen JH, Chang CC, Chen YT, Hsih CJ, Huang H, Lin BS

            Q-Switched Laser Pigmentation

            This study tested the efficacy of a low-fluence, multi-pass Q-switched protocol at both 532 nm and 1064 nm wavelengths for overall facial skin depigmentation and rejuvenation. The toning approach, using subthreshold energy across multiple passes, proved effective for diffuse pigmentation and overall skin brightening without the downtime of higher-fluence ablative protocols.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation
            Health Canada: Yes

            Using a Low-Fluence Q-Switched 532/1064 nm Nd:YAG Laser for Facial Skin Depigmentation

            Peer-Reviewed Dermatology Journal (SCIE/SCOPUS Indexed) – 2016

            Shen JH, Chang CC, Chen YT, Hsih CJ, Huang H, Lin BS

            Q-Switched Laser Pigmentation

            This study tested the efficacy of a low-fluence, multi-pass Q-switched protocol at both 532 nm and 1064 nm wavelengths for overall facial skin depigmentation and rejuvenation. The toning approach, using subthreshold energy across multiple passes, proved effective for diffuse pigmentation and overall skin brightening without the downtime of higher-fluence ablative protocols.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation
            Health Canada: Yes

            Successful Treatment of Refractory Melasma Using Invasive Micro-Pulsed Electric Stimulation

            Aesthetic Dermatology Journal – 2015

            Moon Choi, Seohee Choi, Jin-Soo Kang, and Sung Bin Cho

            Q-Switched Laser Pigmentation Rejuvenation

            This study addressed the challenge of refractory melasma — cases that have not responded to conventional topical or laser approaches — using a micro-pulsed technique. The protocol produced notable lightening of resistant melasma patches with manageable recovery, offering an option for patients who have failed prior treatment lines.

            Device: Helios III
            Technology: Q-Switched Laser
            Indication: Pigmentation, Rejuvenation
            Health Canada: Yes

            Looking for clinical marketing support?

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              Noon Aesthetics

              The Efficacy and Safety of NOON’s Patented DermShield Technology: A Clinical Evaluation

              Journal of Drugs in Dermatology (JDD) – 2021

              Artzi O, M.D, Heyman L, M.D, Carasso R, M.D, Mehrabi J, MSc

              Chemical Peels Anti-Inflammation Redness Rejuvenation

              This peer-reviewed study, published in the Journal of Drugs in Dermatology, evaluated the efficacy and tolerability of NOON DermShield across a patient cohort with compromised skin barrier function. Results confirmed the formulation's protective and regenerative properties, with statistically significant improvement in transepidermal water loss (TEWL) measurements and patient-reported skin comfort scores.

              Device: Noon Aesthetics
              Technology: Chemical Peels
              Indication: Anti-Inflammation, Redness, Rejuvenation
              Health Canada: Yes

              Looking for clinical marketing support?

              If you are looking for a specific clinical resource or support material, fill in your details and we’ll get back to you.

                By submitting this inquiry form you confirm that your information will be added to our mailing list and that you have read the DermaSpark Products Privacy Policy. You can unsubscribe at any time.

                ReadyMedical

                ReadyMedical ANTIOXIDANT VIT C – Antioxidant activity In-Vitro Test by the University of Pavia, Italy

                BIO BASIC Laboratories Independent Testing – 2019

                BIO BASIC Laboratories

                ReadyMedical Pigmentation Rejuvenation

                This independent laboratory study evaluated the antioxidant activity of ReadyMedical ANTIOXIDANT VIT C on irradiated human keratinocytes. Results show that even at low concentrations of 0.0156 mg/ml, the product provides a remarkable protection of irradiated skin cells, with 75% more ROS reduction compared to the study control

                Device: ReadyMedical
                Technology: ReadyMedical
                Indication: Pigmentation, Rejuvenation
                Health Canada: Yes

                ReadyMedical ACNYCID – Anti-Inflammatory In-Vitro Test by the University of Pavia, Italy

                UB-CARE Laboratories Independent Testing – 2018

                UB-CARE Laboratories

                ReadyMedical Acne Anti-Inflammation Redness

                This independent laboratory study evaluated the anti-inflammatory activity of ReadyMedical ACNYCID on Acne-stimulated human keratinocytes. Results show a significant 39%-41% reduction of inflammatory markers, 8h after treatment

                Device: ReadyMedical
                Technology: ReadyMedical
                Indication: Acne, Anti-Inflammation, Redness
                Health Canada: Yes

                ReadyMedical ACNYCID – Anti-Inflammatory In-Vitro Test by the University of Pavia, Italy

                UB-CARE Laboratories Independent Testing – 2018

                UB-CARE Laboratories

                ReadyMedical Acne Anti-Inflammation Redness

                This independent laboratory study evaluated the anti-inflammatory activity of ReadyMedical ACNYCID on Acne-stimulated human keratinocytes. Results show a significant 39%-41% reduction of inflammatory markers, 8h after treatment

                Device: ReadyMedical
                Technology: ReadyMedical
                Indication: Acne, Anti-Inflammation, Redness
                Health Canada: Yes

                ReadyMedical ACNYCID – Antibacterial In-Vitro Test by the University of Pavia, Italy

                UB-CARE Laboratories Independent Testing – 2018

                UB-CARE Laboratories

                ReadyMedical Acne

                This independent laboratory study evaluated the inhibition of C. Acne bacterial growth after treatment with ReadyMedical ACNYCID. Results show a significant 99.9% reduction of bacterial growth after 6h and 24h of treatment.

                Device: ReadyMedical
                Technology: ReadyMedical
                Indication: Acne
                Health Canada: Yes

                ReadyMedical POST-TREATMENT – Anti-Inflammatory In-Vitro Test by the University of Pavia, Italy

                UB-CARE Laboratories Independent Testing – 2017

                UB-CARE Laboratories

                ReadyMedical Anti-Inflammation Rejuvenation

                This independent laboratory study evaluated the anti-inflammatory activity of ReadyMedical ACNYCID on stimulated human fibroblasts. Results show a highly significant 94% reduction of inflammatory markers, 24h after treatment

                Device: ReadyMedical
                Technology: ReadyMedical
                Indication: Anti-Inflammation, Rejuvenation
                Health Canada: Yes

                ReadyMedical REVITALIZING PEPTIDES – Cell Proliferation In-Vitro Test by the University of Pavia, Italy

                UB-CARE Laboratories Independent Testing – 2017

                UB-CARE Laboratories

                ReadyMedical Rejuvenation Wound Healing

                This independent laboratory study evaluated the cell proliferation and wound healing activity of ReadyMedical REVITALIZING PEPTIDES on stimulated human fibroblasts. Results show a significant 44% increase in cell motility and viability, 48h after treatment.

                Device: ReadyMedical
                Technology: ReadyMedical
                Indication: Rejuvenation, Wound Healing
                Health Canada: Yes

                ReadyMedical REVITALIZING PEPTIDES – Cell Proliferation In-Vitro Test by the University of Pavia, Italy

                UB-CARE Laboratories Independent Testing – 2017

                UB-CARE Laboratories

                ReadyMedical Rejuvenation Wound Healing

                This independent laboratory study evaluated the cell proliferation and wound healing activity of ReadyMedical REVITALIZING PEPTIDES on stimulated human fibroblasts. Results show a significant 44% increase in cell motility and viability, 48h after treatment.

                Device: ReadyMedical
                Technology: ReadyMedical
                Indication: Rejuvenation, Wound Healing
                Health Canada: Yes

                Looking for clinical marketing support?

                If you are looking for a specific clinical resource or support material, fill in your details and we’ll get back to you.

                  By submitting this inquiry form you confirm that your information will be added to our mailing list and that you have read the DermaSpark Products Privacy Policy. You can unsubscribe at any time.

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